Elevated Kappa Light Chain In Urine

In the clip dr.

Elevated kappa light chain in urine. Prevalence and clinical significance of abnormal serum kappa lambda light chain ratio in patients with chronic kidney disease our results suggest that an abnormal kappa lambda ratio in most cases higher than normal is a common and most likely nonspecific finding in patients with proteinuria or ckd of an unknown origin or both. The detection of monoclonal light chains in the urine bence jones proteinuria. There are 2 types of light chains called kappa and lambda. Pathology just got my blood results back says kappa lambda light chains free with ratio urine came 18 high prostaglandin serum 550.

Thank you for putting things in simple terms and also for the deciphering my myeloma lab results which i printed out. The light chains can show up in the urine. Wbc rbc in urine with 2g d protein. Doctors call this the bence jones protein bjp.

The production of large amounts of monoclonal light chains however can overwhelm this reabsorption mechanism. I guess we are going on a journey and i pray he will come out on the other side. In this patient power segment host dr. Leclair is a patient power host and retired.

Immunoglobulin light chains are usually cleared from blood through the renal glomeruli and reabsorbed in the proximal tubules so that urine light chain concentrations are very low or undetectable. His kappa light chain free serum level is high. Kappa light chain in upep. A kappa lambda k l ratio greater than 6 2 suggests the presence of monoclonal kappa light chains.

Leclair provides a thorough scientific breakdown of light chains and the way they work. Elevated k l chains in serum but ratio normal. What s mean answered by dr. The bence jones protein bjp represents a homogeneous population of immunoglobulin light chains of either kappa type or lambda type and is the product of a presumed single clone of plasma cells.

A greater than 90 decrease suggests treatment response. A k l ratio less than 0 7 suggests the presence of monoclonal lambda light chains. All laboratory results need to be interpreted in the cli. Your article has helped me to understand what this means.

In 24 hour specimens a greater than 90 increase in concentration suggests progression or relapse.