Elevated Kappa Light Chain Ratio

These unlinked chains are known as free light chains.

Elevated kappa light chain ratio. If the amount of free light chains is higher or lower than normal it can mean you have a disorder of the plasma cells. In a healthy individual the total kappa to lambda ratio is roughly 2 1 in serum measuring intact whole antibodies or 1 1 5 if measuring free light chains with a highly divergent ratio indicative of neoplasm. The ratio or proportion between the kappa and lambda light chains indicates an excess production of one chain over the other and therefore can be used as an indication of disease progression or remission said dr. She told me not to worry and we ll check again in 3 months.

An abnormal light chain ratio has been defined as a kappa to lambda chain ratio of less than 0 26 or more than 1 65. Abnormal free light chain production has also been reported to be prognostic of a worse outcome in multiple myeloma and chronic lymphocytic leukaemia. The exact normal ratio of kappa to lambda according to a novel polyclonal free light chain assay ranges from 0 26 to 1 65. Told me my kappa light chain is elevated at 26.

Authors aneta niewmierzycka. Epub 2015 jun 3. 5 7 26 3 mg ml. Increased lambda free light chains and a decreased kappa lambda ratio may be seen with plasma cell disorders that produce excess monoclonal lambda light chains.

This balance of kappa and lambda together is called the kappa lambda ratio which can also indicate a change in levels of disease. It is normal for there to be small fluctuations in the uninvolved light chain concentration over time which have no clinical significance at all. Kappa light chain concentration range. Lambda and kappa light chains.

I also have these lab results kappa free light chain serum 47 8 mg l 3 3 19 4 mg l lambda free light chain serum 13 5 mg l 5 7 26 3 mg l kappa lambda ratio serum 3 54 i just want to know how ba read more. In the context of mgus or myeloma significantly increased free light chain production and a markedly abnormal kappa lambda ratio indicate an increased risk of disease progression. A free light chains test measures the amount of lambda and kappa free light chains in the blood. Lambda light chain concentration range.

Normal values for kappa lambda and flc ratio. Prevalence and clinical significance of abnormal serum kappa lambda light chain ratio in patients with chronic kidney disease pol arch med wewn.