Elevated Kappa Light Chains But Normal Ratio

5 7 26 3 mg ml.

Elevated kappa light chains but normal ratio. If the amount of free light chains is higher or lower than normal it can mean you have a disorder of the plasma cells. Our results suggest that an abnormal kappa lambda ratio in most cases higher than normal is a common and most likely nonspecific finding in patients with proteinuria or ckd of an unknown origin or both. The kappa lambda ratio did not correlate with age proteinuria or egfr. Serum free light chains can also be increased usually with a normal kappa lambda ratio with some connective tissue disorders inflammatory conditions neurological conditions and some cancers but are not typically monitored in.

An abnormal light chain ratio has been defined as a kappa to lambda chain ratio of less than 0 26 or more than 1 65. Lambda and kappa light chains. She told me not to worry and we ll check again in 3 months. In a healthy individual the total kappa to lambda ratio is roughly 2 1 in serum measuring intact whole antibodies or 1 1 5 if measuring free light chains with a highly divergent ratio indicative of neoplasm.

What else should i ask answered by dr. The exact normal ratio of kappa to lambda according to a novel polyclonal free light chain assay ranges from 0 26 to 1 65. The specificity of this assay for detection of monoclonal light chains relies on the ratio of free kappa and lambda k l light chains. Abnormal free light chain production has also been reported to be prognostic of a worse outcome in multiple myeloma and chronic lymphocytic leukaemia.

Once an abnormal free light chain flc k l ratio has been demonstrated and a diagnosis has been made the quantitation of the monoclonal light chain is useful for monitoring disease activity. Told me my kappa light chain is elevated at 26. Kappa light chain concentration range. This risk is increased in those with increased free light chain production and an abnormal kappa lambda ratio.

The ratio or proportion between the kappa and lambda light chains indicates an excess production of one chain over the other and therefore can be used as an indication of disease progression or remission said dr. These unlinked chains are known as free light chains. There are two types of light chains. A free light chains test measures the amount of lambda and kappa free light chains in the blood.

Normal values for kappa lambda and flc ratio. Lambda light chain concentration range.